Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma

Shaogui Wan; Yousheng Wu; Xingchun Zhou; Yibing Chen; Jiaze An; Xiaohe Yu; Huiqing Zhang; Hushan Yang; Jinliang Xing

doi:10.1371/journal.pone.0124471

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Peer-reviewed

Research Article

Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma

Shaogui Wan ,

Contributed equally to this work with: Shaogui Wan, Yousheng Wu

Affiliation Institute of Pharmacy, Pharmaceutical College of Henan University, Kaifeng, Henan, China
⨯
Yousheng Wu ,

Contributed equally to this work with: Shaogui Wan, Yousheng Wu

Affiliation State Key Laboratory of Cancer Biology, Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
⨯
Xingchun Zhou,

Affiliation State Key Laboratory of Cancer Biology, Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
⨯
Yibing Chen,

Affiliation State Key Laboratory of Cancer Biology, Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
⨯
Jiaze An,

Affiliation Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China
⨯
Xiaohe Yu,

Affiliation Department of Interventional Radiology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China
⨯
Huiqing Zhang,

Affiliation Department of Pain treatment, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China
⨯
Hushan Yang ,

* E-mail: hushan.yang@jefferson.edu (HY); xingjinliang@163.com (JX)

Affiliation Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
⨯
Jinliang Xing

* E-mail: hushan.yang@jefferson.edu (HY); xingjinliang@163.com (JX)

Affiliation State Key Laboratory of Cancer Biology, Experimental Teaching Center of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China
⨯

Polymorphisms in Genes of Tricarboxylic Acid Cycle Key Enzymes Are Associated with Early Recurrence of Hepatocellular Carcinoma

Shaogui Wan,
Yousheng Wu,
Xingchun Zhou,
Yibing Chen,
Jiaze An,
Xiaohe Yu,
Huiqing Zhang,
Hushan Yang,
Jinliang Xing

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0124471

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Cancer risk factors
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Single nucleotide polymorphisms
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Hepatocellular carcinoma
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Citric acid cycle
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Variant genotypes
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