Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

Iva Sovadinova; Pavel Babica; Hatice Böke; Esha Kumar; Andrew Wilke; Joon-Suk Park; James E. Trosko; Brad L. Upham

doi:10.1371/journal.pone.0124454

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Peer-reviewed

Research Article

Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

Iva Sovadinova,

Affiliations Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America, Research Centre for Toxic Compounds in the Environment—RECETOX, Masaryk University, Kamenice 5, CZ62500, Brno, Czech Republic
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Pavel Babica,

Affiliations Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America, Department of Experimental Phycology and Ecotoxicology, Institute of Botany ASCR, Lidicka 25/27, CZ60200, Brno, Czech Republic
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Hatice Böke,

Affiliation Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America
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Esha Kumar,

Affiliation Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America
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Andrew Wilke,

Affiliation Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America
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Joon-Suk Park,

Affiliations Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America, Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea
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James E. Trosko,

Affiliation Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America
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Brad L. Upham

* E-mail: upham@msu.edu

Affiliation Department of Pediatrics & Human Development; Center for Integrative Toxicology; and the Food Safety & Toxicology Center, Michigan State University, East Lansing, Michigan, 48824, United States of America
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Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model

Iva Sovadinova,
Pavel Babica,
Hatice Böke,
Esha Kumar,
Andrew Wilke,
Joon-Suk Park,
James E. Trosko,
Brad L. Upham

Published: May 29, 2015
https://doi.org/10.1371/journal.pone.0124454

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