8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

Mariell Pettersson; David Bliman; Jimmy Jacobsson; Jesper R. Nilsson; Jaeki Min; Luigi Iconaru; R. Kiplin Guy; Richard W. Kriwacki; Joakim Andréasson; Morten Grøtli

doi:10.1371/journal.pone.0124423

Loading metrics

Open Access

Peer-reviewed

Research Article

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

Mariell Pettersson ,

Contributed equally to this work with: Mariell Pettersson, David Bliman

Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
⨯
David Bliman ,

Contributed equally to this work with: Mariell Pettersson, David Bliman

Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
⨯
Jimmy Jacobsson,

Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
⨯
Jesper R. Nilsson,

Affiliation Department of Chemical and Biological Engineering/Chemistry and Biochemistry, Chalmers University of Technology, Gothenburg, Sweden
⨯
Jaeki Min,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, United States of America
⨯
Luigi Iconaru,

Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, United States of America
⨯
R. Kiplin Guy,

Affiliation Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, United States of America
⨯
Richard W. Kriwacki,

Affiliation Department of Structural Biology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee, United States of America
⨯
Joakim Andréasson,

Affiliation Department of Chemical and Biological Engineering/Chemistry and Biochemistry, Chalmers University of Technology, Gothenburg, Sweden
⨯
Morten Grøtli

* E-mail: grotli@chem.gu.se

Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
⨯

8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

Mariell Pettersson,
David Bliman,
Jimmy Jacobsson,
Jesper R. Nilsson,
Jaeki Min,
Luigi Iconaru,
R. Kiplin Guy,
Richard W. Kriwacki,
Joakim Andréasson,
Morten Grøtli

Published: May 5, 2015
https://doi.org/10.1371/journal.pone.0124423

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Chemical synthesis
Is the Subject Area "Chemical synthesis" applicable to this article?

Thanks for your feedback.
Column chromatography
Is the Subject Area "Column chromatography" applicable to this article?

Thanks for your feedback.
Purines
Is the Subject Area "Purines" applicable to this article?

Thanks for your feedback.
Azides
Is the Subject Area "Azides" applicable to this article?

Thanks for your feedback.
Thin-layer chromatography
Is the Subject Area "Thin-layer chromatography" applicable to this article?

Thanks for your feedback.
Alkynes
Is the Subject Area "Alkynes" applicable to this article?

Thanks for your feedback.
NMR spectroscopy
Is the Subject Area "NMR spectroscopy" applicable to this article?

Thanks for your feedback.
Fluorescence polarization
Is the Subject Area "Fluorescence polarization" applicable to this article?

Thanks for your feedback.