High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

Albin Rudisch; Matthew Richard Dewhurst; Luminita Gabriela Horga; Nina Kramer; Nathalie Harrer; Meng Dong; Heiko van der Kuip; Andreas Wernitznig; Andreas Bernthaler; Helmut Dolznig; Wolfgang Sommergruber

doi:10.1371/journal.pone.0124283

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Open Access

Peer-reviewed

Research Article

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

Albin Rudisch,

Affiliations Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria, Department of Microbiology, Immunobiology and Genetics, Center of Molecular Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria
⨯
Matthew Richard Dewhurst,

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯
Luminita Gabriela Horga,

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯
Nina Kramer,

Affiliation Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria
⨯
Nathalie Harrer,

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯
Meng Dong,

Affiliation Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Baden-Württemberg, Germany
⨯
Heiko van der Kuip,

Affiliation Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tübingen, Stuttgart, Baden-Württemberg, Germany
⨯
Andreas Wernitznig,

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯
Andreas Bernthaler,

Current address: Department of Cancer Research, Bayer HealthCare Pharmaceuticals, Berlin, Germany

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯
Helmut Dolznig,

Affiliation Institute of Medical Genetics, Medical University of Vienna, Vienna, Austria
⨯
Wolfgang Sommergruber

* E-mail: wolfgang.sommergruber@boehringer-ingelheim.com

Affiliation Department of Lead Discovery, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria
⨯

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

Albin Rudisch,
Matthew Richard Dewhurst,
Luminita Gabriela Horga,
Nina Kramer,
Nathalie Harrer,
Meng Dong,
Heiko van der Kuip,
Andreas Wernitznig,
Andreas Bernthaler,
Helmut Dolznig

Published: April 28, 2015
https://doi.org/10.1371/journal.pone.0124283

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