Metformin Suppresses Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-+Leprdb/+Leprdb Mice

Open Access

Peer-reviewed

Research Article

Metformin Suppresses Diethylnitrosamine-Induced Liver Tumorigenesis in Obese and Diabetic C57BL/KsJ-+Lepr^db/+Lepr^db Mice

Tomohiko Ohno ,

Contributed equally to this work with: Tomohiko Ohno, Masahito Shimizu

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Masahito Shimizu ,

Contributed equally to this work with: Tomohiko Ohno, Masahito Shimizu

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Yohei Shirakami ,

* E-mail: ys2443@gifu-u.ac.jp

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Atsushi Baba,

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Takahiro Kochi,

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Masaya Kubota,

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Hisashi Tsurumi,

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Takuji Tanaka,

Affiliation Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan
⨯
Hisataka Moriwaki

Affiliation Department of Gastroenterology/Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
⨯

Carcinogenesis
Is the Subject Area "Carcinogenesis" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
Obesity
Is the Subject Area "Obesity" applicable to this article?

Thanks for your feedback.
Leptin
Is the Subject Area "Leptin" applicable to this article?

Thanks for your feedback.
Fatty liver
Is the Subject Area "Fatty liver" applicable to this article?

Thanks for your feedback.
Insulin resistance
Is the Subject Area "Insulin resistance" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.