Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Thomas Yates; Melanie J. Davies; Joseph Henson; Charlotte Edwardson; David Webb; Danielle H. Bodicoat; M’Balu Webb; Philip Howard; Jackie A. Cooper; Steve E. Humphries; Kamlesh Khunti; Philippa Talmud

doi:10.1371/journal.pone.0124062

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Open Access

Peer-reviewed

Research Article

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Thomas Yates,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
Melanie J. Davies,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
Joseph Henson,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
Charlotte Edwardson ,

* E-mail: ce95@le.ac.uk

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
David Webb,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
Danielle H. Bodicoat,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Leicester-Loughborough Diet, Lifestyle, and Physical Activity Biomedical Research Unit (BRU), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
M’Balu Webb,

Affiliation Leicester Diabetes Centre, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
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Philip Howard,

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
⨯
Jackie A. Cooper,

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
⨯
Steve E. Humphries,

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
⨯
Kamlesh Khunti,

Affiliations Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom, National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care—East Midlands (CLAHRC—EM), Leicester Diabetes Centre, Leicester, United Kingdom
⨯
Philippa Talmud

Affiliation Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, The Rayne Building, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
⨯

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Thomas Yates,
Melanie J. Davies,
Joseph Henson,
Charlotte Edwardson,
David Webb,
Danielle H. Bodicoat,
M’Balu Webb,
Philip Howard,
Jackie A. Cooper,
Steve E. Humphries

Published: May 14, 2015
https://doi.org/10.1371/journal.pone.0124062

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Insulin
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