Skeletal Muscle MicroRNA and Messenger RNA Profiling in Cofilin-2 Deficient Mice Reveals Cell Cycle Dysregulation Hindering Muscle Regeneration

Sarah U. Morton; Mugdha Joshi; Talia Savic; Alan H. Beggs; Pankaj B. Agrawal

doi:10.1371/journal.pone.0123829

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Research Article

Skeletal Muscle MicroRNA and Messenger RNA Profiling in Cofilin-2 Deficient Mice Reveals Cell Cycle Dysregulation Hindering Muscle Regeneration

Sarah U. Morton,

Affiliations Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics & Genomics, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America
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Mugdha Joshi,

Affiliations Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics & Genomics, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America
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Talia Savic,

Affiliations Division of Genetics & Genomics, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America
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Alan H. Beggs,

Affiliations Division of Genetics & Genomics, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America
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Pankaj B. Agrawal

* E-mail: pagrawal@enders.tch.harvard.edu

Affiliations Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Division of Genetics & Genomics, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, The Manton Center for Orphan Disease Research, Boston Children's Hospital, Boston, Massachusetts, United States of America
⨯

Skeletal Muscle MicroRNA and Messenger RNA Profiling in Cofilin-2 Deficient Mice Reveals Cell Cycle Dysregulation Hindering Muscle Regeneration

Sarah U. Morton,
Mugdha Joshi,
Talia Savic,
Alan H. Beggs,
Pankaj B. Agrawal

Published: April 13, 2015
https://doi.org/10.1371/journal.pone.0123829

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MicroRNAs
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Cell cycle and cell division
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Apoptosis
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Gene expression
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Muscle regeneration
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DNA recombination
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Messenger RNA
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