Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways

Yuping Liu; Pingting Zhu; Yingyu Wang; Zhonghong Wei; Li Tao; Zhijie Zhu; Xiaobo Sheng; Siliang Wang; Junshan Ruan; Zhaoguo Liu; Yuzhu Cao; Yunlong Shan; Lihua Sun; Aiyun Wang; Wenxing Chen; Yin Lu

doi:10.1371/journal.pone.0123781

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Open Access

Peer-reviewed

Research Article

Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways

Yuping Liu ,

Contributed equally to this work with: Yuping Liu, Pingting Zhu

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Pingting Zhu ,

Contributed equally to this work with: Yuping Liu, Pingting Zhu

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China, Medical College of Yangzhou University, Yangzhou, China
⨯
Yingyu Wang,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Zhonghong Wei,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Li Tao,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Zhijie Zhu,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Xiaobo Sheng,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Siliang Wang,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Junshan Ruan,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Zhaoguo Liu,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Yuzhu Cao,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Yunlong Shan,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Lihua Sun,

Affiliation School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Aiyun Wang,

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
Wenxing Chen,

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
[ ... ],
Yin Lu

* E-mail: profyinlu@163.com

Affiliations School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China, Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China
⨯
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Antimetastatic Therapies of the Polysulfide Diallyl Trisulfide against Triple-Negative Breast Cancer (TNBC) via Suppressing MMP2/9 by Blocking NF-κB and ERK/MAPK Signaling Pathways

Yuping Liu,
Pingting Zhu,
Yingyu Wang,
Zhonghong Wei,
Li Tao,
Zhijie Zhu,
Xiaobo Sheng,
Siliang Wang,
Junshan Ruan,
Zhaoguo Liu

Published: April 30, 2015
https://doi.org/10.1371/journal.pone.0123781

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