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Open Access

Peer-reviewed

Research Article

Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

Julie Sesen,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Perrine Dahan,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Sarah J. Scotland,

Affiliations INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France, Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Estelle Saland,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Van-Thi Dang,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Anthony Lemarié,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Betty M. Tyler,

Affiliation Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Henry Brem,

Affiliation Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States of America
⨯
Christine Toulas,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Elizabeth Cohen-Jonathan Moyal,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Jean-Emmanuel Sarry,

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯
Nicolas Skuli

* E-mail: nicolas.skuli@inserm.fr

Affiliation INSERM U1037, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France
⨯

Metformin Inhibits Growth of Human Glioblastoma Cells and Enhances Therapeutic Response

Julie Sesen,
Perrine Dahan,
Sarah J. Scotland,
Estelle Saland,
Van-Thi Dang,
Anthony Lemarié,
Betty M. Tyler,
Henry Brem,
Christine Toulas,
Elizabeth Cohen-Jonathan Moyal

x

Published: April 13, 2015
https://doi.org/10.1371/journal.pone.0123721

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Cancer treatment
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Glioma cells
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Apoptosis
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Autophagic cell death
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Mitochondria
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Malignant tumors
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Cell death
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Cancers and neoplasms
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