A Genome Wide Association Study Links Glutamate Receptor Pathway to Sporadic Creutzfeldt-Jakob Disease Risk

• Pascual Sanchez-Juan,

  Affiliation Neurology Department, University Hospital “Marqués de Valdecilla”. Instituto de Investigación “Marqués de Valdecilla” IDIVAL and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Santander, Spain

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• Matthew T. Bishop,

  Affiliation The National Creutzfeldt-Jakob disease Research and Surveillance Unit, University of Edinburgh, United Kingdom

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• Gabor G. Kovacs,

  Affiliation Institute of Neurology, Medical University Vienna, Vienna, Austria

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• Miguel Calero,

  Affiliations Chronic Disease Programme and CIBERNED. Carlos III Institute of Health. Madrid. Spain, Alzheimer Disease Research Unit, CIEN Foundation, Carlos III Institute of Health, Alzheimer Center Reina Sofia Foundation, Madrid, Spain

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• Yurii S. Aulchenko,

  Affiliations Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands, Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia, Novosibirsk State University, Novosibirsk, Russia

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• Anna Ladogana,

  Affiliation Department of Cell Biology and Neurosciences Instituto Superiore di Sanità, Roma, Italy

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• Alison Boyd,

  Affiliation Department of Pathology, The University of Melbourne, Parkville, 3010, Australia

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• Victoria Lewis,

  Affiliation Department of Pathology, The University of Melbourne, Parkville, 3010, Australia

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• Claudia Ponto,

  Affiliation Department of Neurology, Clinical Dementia Centre, University Medical Center and German Center for Neurodegenerative Diseases (DZNE)—site Göttingen, Göttingen, Germany

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• Olga Calero,

  Affiliation Chronic Disease Programme and CIBERNED. Carlos III Institute of Health. Madrid. Spain

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• Anna Poleggi,

  Affiliation Department of Cell Biology and Neurosciences Instituto Superiore di Sanità, Roma, Italy

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• Ángel Carracedo,

  Affiliations Fundación Pública Galega de Medicina Xenómica, CIBERER, Grupo de Medicina Xenómica-Universidad de Santiago de Compostela, Santiago de Compostela, Spain, Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, KSA

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• Sven J. van der Lee,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands

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• Thomas Ströbel,

  Affiliation Institute of Neurology, Medical University Vienna, Vienna, Austria

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• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

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• Albert Hofman,

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands

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• Stéphane Haïk,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, and Inserm, U 1127, and CNRS UMR 7225, and ICM, F-75013, Paris, France; AP-HP, Hôpital de la Pitié Salpêtrière, Cellule Nationale de Référence des maladies de Creutzfeldt-Jakob, F-75013, Paris, France

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• Onofre Combarros,

  Affiliation Neurology Department, University Hospital “Marqués de Valdecilla”. Instituto de Investigación “Marqués de Valdecilla” IDIVAL and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Santander, Spain

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• José Berciano,

  Affiliation Neurology Department, University Hospital “Marqués de Valdecilla”. Instituto de Investigación “Marqués de Valdecilla” IDIVAL and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED). Santander, Spain

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• Andre G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

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• Steven J. Collins,

  Affiliation Department of Pathology, The University of Melbourne, Parkville, 3010, Australia

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• Herbert Budka,

  Affiliation Institute of Neurology, Medical University Vienna, Vienna, Austria

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• Jean-Philippe Brandel,

  Affiliation Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, and Inserm, U 1127, and CNRS UMR 7225, and ICM, F-75013, Paris, France; AP-HP, Hôpital de la Pitié Salpêtrière, Cellule Nationale de Référence des maladies de Creutzfeldt-Jakob, F-75013, Paris, France

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• Jean Louis Laplanche,

  Affiliation Service de biochimie et biologie moleculaire, Laboratoire associé au CNR "ATNC", Hôpital Lariboisiére, AP-HP, Paris, France

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• Maurizio Pocchiari,

  Affiliation Department of Cell Biology and Neurosciences Instituto Superiore di Sanità, Roma, Italy

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• Inga Zerr,

  Affiliation Department of Neurology, Clinical Dementia Centre, University Medical Center and German Center for Neurodegenerative Diseases (DZNE)—site Göttingen, Göttingen, Germany

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• Richard S. G. Knight,

  Affiliation The National Creutzfeldt-Jakob disease Research and Surveillance Unit, University of Edinburgh, United Kingdom

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• Robert G. Will,

  Affiliation The National Creutzfeldt-Jakob disease Research and Surveillance Unit, University of Edinburgh, United Kingdom

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•  [ ... ],
• Cornelia M. van Duijn

  * E-mail: c.vanduijn@erasmusmc.nl

  Affiliation Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands

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