Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity

Zexi Hu; Xiaobo Wan; Rui Hao; Heng Zhang; Li Li; Lin Li; Qiang Xie; Peng Wang; Yibo Gao; She Chen; Min Wei; Zhidong Luan; Aiqun Zhang; Niu Huang; Liang Chen

doi:10.1371/journal.pone.0123623

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Open Access

Peer-reviewed

Research Article

Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity

Zexi Hu,

Affiliations College of Life Sciences, Beijing Normal University, Beijing, 100875, China, National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Xiaobo Wan,

Affiliation National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Rui Hao,

Affiliation BeiGene (Beijing) Co., Ltd., Beijing, 102206, China
⨯
Heng Zhang,

Affiliation The Central Hospital of Lishui City, Zhejiang, 323000 China
⨯
Li Li,

Affiliation National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Lin Li,

Affiliation National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Qiang Xie,

Affiliation Fuzhou Pulmonary Hospital of Fujian, Fujian, 350008, China
⨯
Peng Wang,

Affiliation Beijing Ditan Hospital, Beijing, 100015, China
⨯
Yibo Gao,

Affiliation Department of Thoracic Surgery, Cancer Institute and Hospital Chinese Academy of Medical Sciences, Beijing, 100021, China
⨯
She Chen,

Affiliation National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Min Wei,

Affiliation BeiGene (Beijing) Co., Ltd., Beijing, 102206, China
⨯
Zhidong Luan,

Affiliation Liaoning Medical University, Jinzhou, Liaoning, 121001, China
⨯
Aiqun Zhang,

Affiliation The General Hospital of People’s Liberation Army (301 Hospital), Fuxing Road, Beijing, 100853, China
⨯
Niu Huang,

Affiliation National Institute of Biological Sciences, Beijing. Beijing, 102206, China
⨯
Liang Chen

* E-mail: chenliang@nibs.ac.cn

Affiliation Collaborative Innovation Center of Cancer Medicine, National Institute of Biological Sciences, Beijing, Beijing, 102206, China
⨯

Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity

Zexi Hu,
Xiaobo Wan,
Rui Hao,
Heng Zhang,
Li Li,
Lin Li,
Qiang Xie,
Peng Wang,
Yibo Gao,
She Chen

Published: April 8, 2015
https://doi.org/10.1371/journal.pone.0123623

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Phosphorylation
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Transfection
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Tyrosine kinases
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Hepatocellular carcinoma
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Signal inhibition
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Mutation databases
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STAT signaling
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Tyrosine
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