Use of a Conformational Switching Aptamer for Rapid and Specific Ex Vivo Identification of Central Nervous System Lymphoma in a Xenograft Model

Joseph F. Georges; Xiaowei Liu; Jennifer Eschbacher; Joshua Nichols; Michael A. Mooney; Anna Joy; Robert F. Spetzler; Burt G. Feuerstein; Mark C. Preul; Trent Anderson; Hao Yan; Peter Nakaji

doi:10.1371/journal.pone.0123607

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Open Access

Peer-reviewed

Research Article

Use of a Conformational Switching Aptamer for Rapid and Specific Ex Vivo Identification of Central Nervous System Lymphoma in a Xenograft Model

Joseph F. Georges ,

Contributed equally to this work with: Joseph F. Georges, Xiaowei Liu

Current Address: Division of Neurosurgery, Ohio University and Grant Medical Center, Columbus, Ohio

Affiliations Division of Neuroscience, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona, Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Xiaowei Liu ,

Contributed equally to this work with: Joseph F. Georges, Xiaowei Liu

Affiliation The Biodesign Institute, Arizona State University, Tempe, Arizona
⨯
Jennifer Eschbacher,

Affiliation Division of Neuropathology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Joshua Nichols,

Affiliation College of Medicine, University of Arizona, Phoenix, Arizona
⨯
Michael A. Mooney,

Affiliation Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Anna Joy,

Affiliation Division of Neuroscience, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Robert F. Spetzler,

Affiliation Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Burt G. Feuerstein,

Affiliation College of Medicine, University of Arizona, Phoenix, Arizona
⨯
Mark C. Preul,

Affiliation Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯
Trent Anderson,

Affiliation College of Medicine, University of Arizona, Phoenix, Arizona
⨯
Hao Yan,

Affiliation The Biodesign Institute, Arizona State University, Tempe, Arizona
⨯
Peter Nakaji

* E-mail: Neuropub@dignityhealth.org

Affiliation Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, Arizona
⨯

Use of a Conformational Switching Aptamer for Rapid and Specific Ex Vivo Identification of Central Nervous System Lymphoma in a Xenograft Model

Joseph F. Georges,
Xiaowei Liu,
Jennifer Eschbacher,
Joshua Nichols,
Michael A. Mooney,
Anna Joy,
Robert F. Spetzler,
Burt G. Feuerstein,
Mark C. Preul,
Trent Anderson

Published: April 15, 2015
https://doi.org/10.1371/journal.pone.0123607

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