An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

Emily K. Kleczko; Jihye Kim; Stephen B. Keysar; Lydia R. Heasley; Justin R. Eagles; Matthew Simon; Marianne E. Marshall; Katherine R. Singleton; Antonio Jimeno; Aik-Choon Tan; Lynn E. Heasley

doi:10.1371/journal.pone.0123600

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Peer-reviewed

Research Article

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

Emily K. Kleczko ,

* E-mail: emily.kleczko@ucdenver.edu

Affiliation Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Jihye Kim,

Affiliation Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Stephen B. Keysar,

Affiliation Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Lydia R. Heasley,

Affiliation Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Justin R. Eagles,

Affiliation Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Matthew Simon,

Affiliation Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Marianne E. Marshall,

Affiliation Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Katherine R. Singleton,

Affiliation Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Antonio Jimeno,

Affiliation Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Aik-Choon Tan,

Affiliation Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Lynn E. Heasley

Affiliations Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Veterans Affairs Eastern Colorado Healthcare System, Denver, Colorado, United States of America
⨯

An Inducible TGF-β2-TGFβR Pathway Modulates the Sensitivity of HNSCC Cells to Tyrosine Kinase Inhibitors Targeting Dominant Receptor Tyrosine Kinases

Emily K. Kleczko,
Jihye Kim,
Stephen B. Keysar,
Lydia R. Heasley,
Justin R. Eagles,
Matthew Simon,
Marianne E. Marshall,
Katherine R. Singleton,
Antonio Jimeno,
Aik-Choon Tan

Published: May 6, 2015
https://doi.org/10.1371/journal.pone.0123600

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TGF-beta signaling cascade
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