Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Diana Ortiz; W. Armand Guiguemde; Alex Johnson; Carolyn Elya; Johanna Anderson; Julie Clark; Michele Connelly; Lei Yang; Jaeki Min; Yuko Sato; R. Kiplin Guy; Scott M. Landfear

doi:10.1371/journal.pone.0123598

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Open Access

Peer-reviewed

Research Article

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Diana Ortiz ,

Contributed equally to this work with: Diana Ortiz, W. Armand Guiguemde

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯
W. Armand Guiguemde ,

Contributed equally to this work with: Diana Ortiz, W. Armand Guiguemde

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Alex Johnson,

Current address: Department of Chemical and Systems Biology, Stanford University School of Medicine, Palo Alto, CA, United States of America

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯
Carolyn Elya,

Current address: Department of Molecular and Cell Biology, University of California, Berkley, CA, United States of America

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯
Johanna Anderson,

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯
Julie Clark,

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Michele Connelly,

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Lei Yang,

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Jaeki Min,

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Yuko Sato,

Current address: Max Planck Institute for Infection Biology, Charitéplatz 1, D-10117, Berlin, Germany

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯
R. Kiplin Guy,

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, TN, United States of America
⨯
Scott M. Landfear

* E-mail: landfear@ohsu.edu

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR, United States of America
⨯

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Diana Ortiz,
W. Armand Guiguemde,
Alex Johnson,
Carolyn Elya,
Johanna Anderson,
Julie Clark,
Michele Connelly,
Lei Yang,
Jaeki Min,
Yuko Sato

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0123598

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