Down-Regulation of MicroRNA-223 Promotes Degranulation via the PI3K/Akt Pathway by Targeting IGF-1R in Mast Cells

Open Access

Peer-reviewed

Research Article

Quan Wang ,

Contributed equally to this work with: Quan Wang, De-Yu Zhao

Affiliation Department of Respiratory Medicine, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
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De-Yu Zhao ,

Contributed equally to this work with: Quan Wang, De-Yu Zhao

Affiliation Department of Respiratory Medicine, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
⨯
Hong Xu,

Affiliation Department of Respiratory Medicine, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
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Hui Zhou,

Affiliation Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University, Nanjing, China
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Qian-Yuan Yang,

Affiliation Department of Respiratory Medicine, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
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Feng Liu ,

* E-mail: axsliu@163.com (FL); gpzhou@aliyun.com (GPZ)

Affiliation Department of Respiratory Medicine, Nanjing Children’s Hospital Affiliated to Nanjing Medical University, Nanjing, China
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Guo-Ping Zhou

* E-mail: axsliu@163.com (FL); gpzhou@aliyun.com (GPZ)

Affiliation Department of Pediatrics, the Frist Affiliated Hospital of Nanjing Medical University, Nanjing, China
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Mast cells
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Cell degranulation
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Transfection
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Inflammatory diseases
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Luciferase
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MicroRNAs
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Transcription factors
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Electrophoretic mobility shift assay
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