Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

Nikisha Carty; Nadège Berson; Karsten Tillack; Christina Thiede; Diana Scholz; Karsten Kottig; Yalda Sedaghat; Christina Gabrysiak; George Yohrling; Heinz von der Kammer; Andreas Ebneth; Volker Mack; Ignacio Munoz-Sanjuan; Seung Kwak

doi:10.1371/journal.pone.0123527

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Open Access

Peer-reviewed

Research Article

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

Nikisha Carty ,

Contributed equally to this work with: Nikisha Carty, Nadège Berson, Karsten Tillack

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Nadège Berson ,

Contributed equally to this work with: Nikisha Carty, Nadège Berson, Karsten Tillack

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Karsten Tillack ,

Contributed equally to this work with: Nikisha Carty, Nadège Berson, Karsten Tillack

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Christina Thiede,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Diana Scholz,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Karsten Kottig,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Yalda Sedaghat,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Christina Gabrysiak,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
George Yohrling,

Affiliation CHDI Management/CHDI Foundation, Princeton, New Jersey, United States of America
⨯
Heinz von der Kammer,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Andreas Ebneth,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Volker Mack,

Affiliation Evotec AG, Manfred Eigen Campus, Hamburg, Germany
⨯
Ignacio Munoz-Sanjuan,

Affiliation CHDI Management/CHDI Foundation, Princeton, New Jersey, United States of America
⨯
Seung Kwak

* E-mail: Seung.kwak@chdifoundation.org

Affiliation CHDI Management/CHDI Foundation, Princeton, New Jersey, United States of America
⨯

Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

Nikisha Carty,
Nadège Berson,
Karsten Tillack,
Christina Thiede,
Diana Scholz,
Karsten Kottig,
Yalda Sedaghat,
Christina Gabrysiak,
George Yohrling,
Heinz von der Kammer

Published: April 10, 2015
https://doi.org/10.1371/journal.pone.0123527

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