Anti-Yo Antibody Uptake and Interaction with Its Intracellular Target Antigen Causes Purkinje Cell Death in Rat Cerebellar Slice Cultures: A Possible Mechanism for Paraneoplastic Cerebellar Degeneration in Humans with Gynecological or Breast Cancers

John E. Greenlee; Susan A. Clawson; Kenneth E. Hill; Blair Wood; Stacey L. Clardy; Ikuo Tsunoda; Noel G. Carlson

doi:10.1371/journal.pone.0123446

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Research Article

Anti-Yo Antibody Uptake and Interaction with Its Intracellular Target Antigen Causes Purkinje Cell Death in Rat Cerebellar Slice Cultures: A Possible Mechanism for Paraneoplastic Cerebellar Degeneration in Humans with Gynecological or Breast Cancers

John E. Greenlee ,

* E-mail: john.greenlee@hsc.utah.edu

Affiliations Neurology Service, George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Susan A. Clawson,

Affiliation Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Kenneth E. Hill,

Affiliation Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Blair Wood,

Affiliation Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Stacey L. Clardy,

Affiliations Neurology Service, George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America, Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯
Ikuo Tsunoda,

Affiliation Department of Microbiology and Immunology Center for Molecular and Tumor Virology (CMTV), Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Noel G. Carlson

Affiliations Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America, Geriatric Research, Education, and Care Center (GRECC), George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America, Research Service, George E. Wahlen Veterans Affairs Health Care System, Salt Lake City, Utah, United States of America, Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
⨯

Anti-Yo Antibody Uptake and Interaction with Its Intracellular Target Antigen Causes Purkinje Cell Death in Rat Cerebellar Slice Cultures: A Possible Mechanism for Paraneoplastic Cerebellar Degeneration in Humans with Gynecological or Breast Cancers

John E. Greenlee,
Susan A. Clawson,
Kenneth E. Hill,
Blair Wood,
Stacey L. Clardy,
Ikuo Tsunoda,
Noel G. Carlson

Published: April 17, 2015
https://doi.org/10.1371/journal.pone.0123446

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Purkinje cells
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Cell death
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Immunohistochemistry techniques
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Antibodies
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