Peripheral Opioid Antagonist Enhances the Effect of Anti-Tumor Drug by Blocking a Cell Growth-Suppressive Pathway In Vivo

• Masami Suzuki ,

  Contributed equally to this work with: Masami Suzuki, Fumiko Chiwaki

  Affiliation Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan

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• Fumiko Chiwaki ,

  Contributed equally to this work with: Masami Suzuki, Fumiko Chiwaki

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo, Japan

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• Yumi Sawada,

  Affiliation Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan

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• Maho Ashikawa,

  Affiliation Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan

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• Kazuhiko Aoyagi,

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo, Japan

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• Takeshi Fujita,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Kazuyoshi Yanagihara,

  Affiliation Division of Translational Research, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center Hospital East, Chiba, Japan

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• Masayuki Komatsu,

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo, Japan

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• Minoru Narita,

  Affiliation Department of Pharmacology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan

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• Tsutomu Suzuki,

  Affiliation Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan

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• Hiroshi Nagase,

  Affiliation International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Japan

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• Ryoji Kushima,

  Affiliation Department of Pathology, National Cancer Center Hospital, Tokyo, Japan

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• Hiromi Sakamoto,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Takeo Fukagawa,

  Affiliation Gastric Surgery Division, National Cancer Center Hospital, Tokyo, Japan

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• Hitoshi Katai,

  Affiliation Gastric Surgery Division, National Cancer Center Hospital, Tokyo, Japan

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• Hitoshi Nakagama,

  Affiliation Division of Cancer Development System, National Cancer Center Research Institute, Tokyo, Japan

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• Teruhiko Yoshida,

  Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan

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• Yasuhito Uezono ,

  ¶‡ These authors are the project co-leaders joint senior authors on this work.

  Affiliation Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tokyo, Japan

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•  [ ... ],
• Hiroki Sasaki

  * E-mail: hksasaki@ncc.go.jp

  ¶‡ These authors are the project co-leaders joint senior authors on this work.

  Affiliations Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo, Japan

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