A Novobiocin Derivative, XN4, Inhibits the Proliferation of Chronic Myeloid Leukemia Cells by Inducing Oxidative DNA Damage

Lixian Wu; Xianling Chen; Lisen Huang; Jue Tian; Fang Ke; Jianhua Xu; Yuanzhong Chen; Ming Zheng

doi:10.1371/journal.pone.0123314

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Research Article

A Novobiocin Derivative, XN4, Inhibits the Proliferation of Chronic Myeloid Leukemia Cells by Inducing Oxidative DNA Damage

Lixian Wu ,

Contributed equally to this work with: Lixian Wu, Xianling Chen

* E-mail: wlx-lisa@126.com (LW); zming_1956@163.com (MZ)

Affiliations Department of Pharmacology, School of Pharmacy, Fujian Medical University (FMU), Fuzhou, P. R.China, Institute of Materia Medica, FMU, Fuzhou, P. R.China, Fuijan Key Laboratory of Natural Medicine pharmacology, FMU, Fuzhou, P. R.China
⨯
Xianling Chen ,

Contributed equally to this work with: Lixian Wu, Xianling Chen

Affiliation Fujian Institute of Hematology, Union Hospital, FMU, Fuzhou, P. R.China
⨯
Lisen Huang,

Affiliations Department of Pharmacology, School of Pharmacy, Fujian Medical University (FMU), Fuzhou, P. R.China, Institute of Materia Medica, FMU, Fuzhou, P. R.China, Fuijan Key Laboratory of Natural Medicine pharmacology, FMU, Fuzhou, P. R.China
⨯
Jue Tian,

Affiliations Department of Pharmacology, School of Pharmacy, Fujian Medical University (FMU), Fuzhou, P. R.China, Institute of Materia Medica, FMU, Fuzhou, P. R.China, Fuijan Key Laboratory of Natural Medicine pharmacology, FMU, Fuzhou, P. R.China
⨯
Fang Ke,

Affiliation Department of Pharmacochemistry, School of Pharmacy, FMU, Fuzhou, P. R.China
⨯
Jianhua Xu,

Affiliations Department of Pharmacology, School of Pharmacy, Fujian Medical University (FMU), Fuzhou, P. R.China, Institute of Materia Medica, FMU, Fuzhou, P. R.China, Fuijan Key Laboratory of Natural Medicine pharmacology, FMU, Fuzhou, P. R.China
⨯
Yuanzhong Chen,

Affiliation Fujian Institute of Hematology, Union Hospital, FMU, Fuzhou, P. R.China
⨯
Ming Zheng

* E-mail: wlx-lisa@126.com (LW); zming_1956@163.com (MZ)

Affiliation Department of Anatomy, School of Basic Medicine, FMU, Fuzhou, P. R.China
⨯

A Novobiocin Derivative, XN4, Inhibits the Proliferation of Chronic Myeloid Leukemia Cells by Inducing Oxidative DNA Damage

Lixian Wu,
Xianling Chen,
Lisen Huang,
Jue Tian,
Fang Ke,
Jianhua Xu,
Yuanzhong Chen,
Ming Zheng

Published: April 30, 2015
https://doi.org/10.1371/journal.pone.0123314

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