Specific Uptake and Genotoxicity Induced by Polystyrene Nanobeads with Distinct Surface Chemistry on Human Lung Epithelial Cells and Macrophages

Vincent Paget; Samir Dekali; Thierry Kortulewski; Romain Grall; Christelle Gamez; Kelly Blazy; Olivier Aguerre-Chariol; Sylvie Chevillard; Anne Braun; Patrice Rat; Ghislaine Lacroix

doi:10.1371/journal.pone.0123297

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Open Access

Peer-reviewed

Research Article

Specific Uptake and Genotoxicity Induced by Polystyrene Nanobeads with Distinct Surface Chemistry on Human Lung Epithelial Cells and Macrophages

Vincent Paget ,

Contributed equally to this work with: Vincent Paget, Samir Dekali

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯
Samir Dekali ,

Contributed equally to this work with: Vincent Paget, Samir Dekali

Affiliations Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France, Laboratoire de chimie et toxicologie analytique et cellulaire (C-TAC) / UMR CNRS 8638, Faculté de Pharmacie de Paris, Université Paris Descartes (PRES Sorbonne Paris Cité), Paris, France
⨯
Thierry Kortulewski,

Affiliation CEA, DSV, iRCM, Plateforme imagerie photonique, Fontenay-aux-Roses, France
⨯
Romain Grall,

Affiliation CEA, DSV, iRCM, Laboratoire Cancérologie Expérimentale (LCE), Fontenay-aux-Roses, France
⨯
Christelle Gamez,

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯
Kelly Blazy,

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯
Olivier Aguerre-Chariol,

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯
Sylvie Chevillard,

Affiliation CEA, DSV, iRCM, Laboratoire Cancérologie Expérimentale (LCE), Fontenay-aux-Roses, France
⨯
Anne Braun,

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯
Patrice Rat,

Affiliation Laboratoire de chimie et toxicologie analytique et cellulaire (C-TAC) / UMR CNRS 8638, Faculté de Pharmacie de Paris, Université Paris Descartes (PRES Sorbonne Paris Cité), Paris, France
⨯
Ghislaine Lacroix

* E-mail: ghislaine.lacroix@ineris.fr

Affiliation Institut National de l'Environnement Industriel et des Risques (INERIS), Unité de Toxicologie Expérimentale, Parc Technologique ALATA, BP2, Verneuil-en-Halatte, France
⨯

Specific Uptake and Genotoxicity Induced by Polystyrene Nanobeads with Distinct Surface Chemistry on Human Lung Epithelial Cells and Macrophages

Vincent Paget,
Samir Dekali,
Thierry Kortulewski,
Romain Grall,
Christelle Gamez,
Kelly Blazy,
Olivier Aguerre-Chariol,
Sylvie Chevillard,
Anne Braun,
Patrice Rat

Published: April 15, 2015
https://doi.org/10.1371/journal.pone.0123297

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