An Essential Signal Peptide Peptidase Identified in an RNAi Screen of Serine Peptidases of Trypanosoma brucei

Open Access

Peer-reviewed

Research Article

Catherine X. Moss ,

* E-mail: catherinexmoss@gmail.com

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Elaine Brown,

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Alana Hamilton,

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Pieter Van der Veken,

Affiliation Medicinal Chemistry (UAMC), Department of Pharmaceutical Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium
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Koen Augustyns,

Affiliation Medicinal Chemistry (UAMC), Department of Pharmaceutical Sciences, University of Antwerp, Wilrijk, Antwerp, Belgium
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Jeremy C. Mottram

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Proteases
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RNA interference
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Serine
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Trypanosoma brucei gambiense
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Signal peptidases
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Parasitic diseases
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Gene targeting
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Drug discovery
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