An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist

Eswarkumar Nadendla; Catherine Teyssier; Vanessa Delfosse; Valérie Vivat; Gunasekaran Krishnasamy; Hinrich Gronemeyer; William Bourguet; Pierre Germain

doi:10.1371/journal.pone.0123195

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Research Article

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist

Eswarkumar Nadendla ,

Contributed equally to this work with: Eswarkumar Nadendla, Catherine Teyssier

Affiliations Inserm U1054, Centre de Biochimie Structurale, Montpellier, France, CNRS UMR5048, Universités Montpellier 1 & 2, Montpellier, France, CAS in Crystallography and Biophysics, University of Madras, Chennai, India
⨯
Catherine Teyssier ,

Contributed equally to this work with: Eswarkumar Nadendla, Catherine Teyssier

Current address: IRCM, Inserm U896, Montpellier, France

Affiliations Inserm U1054, Centre de Biochimie Structurale, Montpellier, France, CNRS UMR5048, Universités Montpellier 1 & 2, Montpellier, France
⨯
Vanessa Delfosse,

Affiliations Inserm U1054, Centre de Biochimie Structurale, Montpellier, France, CNRS UMR5048, Universités Montpellier 1 & 2, Montpellier, France
⨯
Valérie Vivat,

Affiliation Novalix, Illkirch, C.U. de Strasbourg, France
⨯
Gunasekaran Krishnasamy,

Affiliation CAS in Crystallography and Biophysics, University of Madras, Chennai, India
⨯
Hinrich Gronemeyer,

Affiliation IGBMC, CNRS/INSERM/UdS/CERBM, Illkirch-Cedex, C.U. de Strasbourg, France
⨯
William Bourguet ,

* E-mail: bourguet@cbs.cnrs.fr (WB); germain@cbs.cnrs.fr (PG)

Affiliations Inserm U1054, Centre de Biochimie Structurale, Montpellier, France, CNRS UMR5048, Universités Montpellier 1 & 2, Montpellier, France
⨯
Pierre Germain

* E-mail: bourguet@cbs.cnrs.fr (WB); germain@cbs.cnrs.fr (PG)

Affiliations Inserm U1054, Centre de Biochimie Structurale, Montpellier, France, CNRS UMR5048, Universités Montpellier 1 & 2, Montpellier, France
⨯

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist

Eswarkumar Nadendla,
Catherine Teyssier,
Vanessa Delfosse,
Valérie Vivat,
Gunasekaran Krishnasamy,
Hinrich Gronemeyer,
William Bourguet,
Pierre Germain

Published: May 1, 2015
https://doi.org/10.1371/journal.pone.0123195

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