New Point Mutations in Surface and Core Genes of Hepatitis B Virus Associated with Acute on Chronic Liver Failure Identified by Complete Genomic Sequencing

Hangdi Xu; Mingfei Zhao; Guohua Lou; Min Zheng; Qingyi Cao; Zhi Chen

doi:10.1371/journal.pone.0123139

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Peer-reviewed

Research Article

New Point Mutations in Surface and Core Genes of Hepatitis B Virus Associated with Acute on Chronic Liver Failure Identified by Complete Genomic Sequencing

Hangdi Xu ,

Contributed equally to this work with: Hangdi Xu, Mingfei Zhao

Affiliation Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Mingfei Zhao ,

Contributed equally to this work with: Hangdi Xu, Mingfei Zhao

Affiliation Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Guohua Lou,

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang, China
⨯
Min Zheng,

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang, China
⨯
Qingyi Cao,

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang, China
⨯
Zhi Chen

* E-mail: zju.zhichen@gmail.com

Affiliation State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang, China
⨯

New Point Mutations in Surface and Core Genes of Hepatitis B Virus Associated with Acute on Chronic Liver Failure Identified by Complete Genomic Sequencing

Hangdi Xu,
Mingfei Zhao,
Guohua Lou,
Min Zheng,
Qingyi Cao,
Zhi Chen

Published: April 7, 2015
https://doi.org/10.1371/journal.pone.0123139

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Hepatitis B virus
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Microbial mutation
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Chronic hepatitis
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DNA sequencing
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Substitution mutation
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