ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic Compartments

Lianwu Fu; Andras Rab; Li ping Tang; Zsuzsa Bebok; Steven M. Rowe; Rafal Bartoszewski; James F. Collawn

doi:10.1371/journal.pone.0123131

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Peer-reviewed

Research Article

ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic Compartments

Lianwu Fu ,

* E-mail: lianwufu@uab.edu (LF); jcollawn@uab.edu (JFC)

Affiliations Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Andras Rab,

Affiliations Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Li ping Tang,

Affiliations Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Zsuzsa Bebok,

Affiliations Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Steven M. Rowe,

Affiliations Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Rafal Bartoszewski,

Affiliation Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, Gdansk, Poland
⨯
James F. Collawn

* E-mail: lianwufu@uab.edu (LF); jcollawn@uab.edu (JFC)

Affiliations Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

ΔF508 CFTR Surface Stability Is Regulated by DAB2 and CHIP-Mediated Ubiquitination in Post-Endocytic Compartments

Lianwu Fu,
Andras Rab,
Li ping Tang,
Zsuzsa Bebok,
Steven M. Rowe,
Rafal Bartoszewski,
James F. Collawn

Published: April 16, 2015
https://doi.org/10.1371/journal.pone.0123131

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Endocytosis
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Small interfering RNA
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Transfection
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Ubiquitination
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Epithelial cells
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