SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness

Jason W. Rausch; Meijuan Tian; Yuejin Li; Lora Angelova; Bernard S. Bagaya; Kendall C. Krebs; Feng Qian; Chuanwu Zhu; Eric J. Arts; Stuart F. J. Le Grice; Yong Gao

doi:10.1371/journal.pone.0122953

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Open Access

Peer-reviewed

Research Article

SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness

Jason W. Rausch,

Affiliation HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Meijuan Tian,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Yuejin Li,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Lora Angelova,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Bernard S. Bagaya,

Affiliation Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Kendall C. Krebs,

Affiliation Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯
Feng Qian,

Affiliation Suzhou Fifth People’s Hospital, Suzhou, Jiangsu, China
⨯
Chuanwu Zhu,

Affiliation Suzhou Fifth People’s Hospital, Suzhou, Jiangsu, China
⨯
Eric J. Arts,

Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada
⨯
Stuart F. J. Le Grice,

Affiliation HIV Drug Resistance Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America
⨯
Yong Gao

* E-mail: yong.gao@case.edu

Affiliations Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
⨯

SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness

Jason W. Rausch,
Meijuan Tian,
Yuejin Li,
Lora Angelova,
Bernard S. Bagaya,
Kendall C. Krebs,
Feng Qian,
Chuanwu Zhu,
Eric J. Arts,
Stuart F. J. Le Grice

Published: April 10, 2015
https://doi.org/10.1371/journal.pone.0122953

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HIV-1
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