Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of IKs and Ca2+ Cycling

Emily Lau; Konstantinos Kossidas; Tae Yun Kim; Yukiko Kunitomo; Ohad Ziv; Song Zhen; Chantel Taylor; Lorraine Schofield; Joe Yammine; Gongxin Liu; Xuwen Peng; Zhilin Qu; Gideon Koren; Bum-Rak Choi

doi:10.1371/journal.pone.0122754

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Research Article

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I_Ks and Ca²⁺ Cycling

Emily Lau ,

Contributed equally to this work with: Emily Lau, Konstantinos Kossidas

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯
Konstantinos Kossidas ,

Contributed equally to this work with: Emily Lau, Konstantinos Kossidas

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯
Tae Yun Kim,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Yukiko Kunitomo,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Ohad Ziv,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Song Zhen,

Affiliation Department of Medicine (Cardiology), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
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Chantel Taylor,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Lorraine Schofield,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Joe Yammine,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Gongxin Liu,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Xuwen Peng,

Affiliation Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
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Zhilin Qu,

Affiliation Department of Medicine (Cardiology), David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
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Gideon Koren,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
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Bum-Rak Choi

* E-mail: bum-rak_choi@brown.edu

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯

Spatially Discordant Alternans and Arrhythmias in Tachypacing-Induced Cardiac Myopathy in Transgenic LQT1 Rabbits: The Importance of I_Ks and Ca²⁺ Cycling

Emily Lau,
Konstantinos Kossidas,
Tae Yun Kim,
Yukiko Kunitomo,
Ohad Ziv,
Song Zhen,
Chantel Taylor,
Lorraine Schofield,
Joe Yammine,
Gongxin Liu

Published: May 13, 2015
https://doi.org/10.1371/journal.pone.0122754

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