Statistical Distance as a Measure of Physiological Dysregulation Is Largely Robust to Variation in Its Biomarker Composition

• Alan A. Cohen ,

  * E-mail: Alan.Cohen@USherbrooke.ca

  Affiliation Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada

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• Qing Li ,

  Contributed equally to this work with: Qing Li, Emmanuel Milot

  Affiliation Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada

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• Emmanuel Milot ,

  Contributed equally to this work with: Qing Li, Emmanuel Milot

  Affiliation Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351, boul. des Forges, C.P. 500, Trois-Rivières, QC, G9A 5H7, Canada

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• Maxime Leroux,

  Affiliation Economics Department, ESG, Université du Québec à Montréal, 315 rue Sainte-Catherine Est, Montréal, QC, H2X 3X2, Canada

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• Samuel Faucher,

  Affiliation Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada

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• Vincent Morissette-Thomas,

  Affiliation Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada

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• Véronique Legault,

  Affiliation Groupe de recherche PRIMUS, Department of Family Medicine, University of Sherbrooke, 3001 12e Ave N, Sherbrooke, QC, J1H 5N4, Canada

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• Linda P. Fried,

  Affiliation Mailman School of Public Health, Columbia University, 722 W. 168th Street, R1408, New York, NY, 10032, United States of America

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• Luigi Ferrucci

  Affiliation Translational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, MedStar Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD, 21225, United States of America

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