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Open Access
Peer-reviewed
Research Article
Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
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Marcelo González ,
* E-mail: sobrevia@med.puc.cl (LS); aaleiva@uc.cl (AL); mgonzalezo@udec.cl (MG)
Affiliations Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile, Group of Research and Innovation in Vascular Health (GRIVAS-Health), PO-Box 114-D, Chillán 3800708, Chile
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Susana Rojas,
Affiliation Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile
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Pía Avila,
Affiliation Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile
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Lissette Cabrera,
Affiliations Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile, Department of Morphophysiology, Faculty of Medicine, Universidad Diego Portales, Santiago 8370076, Chile
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Roberto Villalobos,
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Carlos Palma,
Affiliation Vascular Physiology Laboratory, Department of Physiology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile
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Claudio Aguayo,
Affiliations Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile, Group of Research and Innovation in Vascular Health (GRIVAS-Health), PO-Box 114-D, Chillán 3800708, Chile
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Eduardo Peña,
Affiliation Department of Physiopathology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile
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Victoria Gallardo,
Affiliation Department of Physiopathology, Faculty of Biological Sciences, Universidad de Concepción, P.O. Box 160-C, Concepción 4070386, Chile
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Enrique Guzmán-Gutiérrez,
Affiliations Group of Research and Innovation in Vascular Health (GRIVAS-Health), PO-Box 114-D, Chillán 3800708, Chile, Faculty of Health Sciences, Universidad San Sebastián, Concepción 4080871, Chile
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Tamara Sáez,
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Rocío Salsoso,
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Carlos Sanhueza,
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Fabián Pardo,
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Andrea Leiva ,
* E-mail: sobrevia@med.puc.cl (LS); aaleiva@uc.cl (AL); mgonzalezo@udec.cl (MG)
Affiliation Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Luis Sobrevia
* E-mail: sobrevia@med.puc.cl (LS); aaleiva@uc.cl (AL); mgonzalezo@udec.cl (MG)
Affiliations University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Queensland, Australia, Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville E-41012, Spain, Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, P.O. Box 114-D, Santiago 8330024, Chile
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Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells
- Marcelo González,
- Susana Rojas,
- Pía Avila,
- Lissette Cabrera,
- Roberto Villalobos,
- Carlos Palma,
- Claudio Aguayo,
- Eduardo Peña,
- Victoria Gallardo,
- Enrique Guzmán-Gutiérrez
- Published: April 14, 2015
- https://doi.org/10.1371/journal.pone.0122398