Association between P16INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

Hao Shi; Xiong Chen; Cheng Lu; Changmei Gu; Hongwei Jiang; RuiWei Meng; Xun Niu; Yangxin Huang; Meixia Lu

doi:10.1371/journal.pone.0122302

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Open Access

Peer-reviewed

Research Article

Association between P16^INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

Hao Shi ,

Contributed equally to this work with: Hao Shi, Xiong Chen

Affiliation Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Xiong Chen ,

Contributed equally to this work with: Hao Shi, Xiong Chen

Affiliation Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Cheng Lu,

Affiliation Department of Anatomy, Medical College of Nanchang University, Nanchang, Jiangxi, China
⨯
Changmei Gu,

Affiliation Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Hongwei Jiang,

Affiliation Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
RuiWei Meng,

Affiliation Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Xun Niu,

Affiliation Department of Otolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Yangxin Huang,

Affiliation Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, United States of America
⨯
Meixia Lu

* E-mail: mlu@hust.edu.cn

Affiliation Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯

Association between P16^INK4a Promoter Methylation and HNSCC: A Meta-Analysis of 21 Published Studies

Hao Shi,
Xiong Chen,
Cheng Lu,
Changmei Gu,
Hongwei Jiang,
RuiWei Meng,
Xun Niu,
Yangxin Huang,
Meixia Lu

Published: April 2, 2015
https://doi.org/10.1371/journal.pone.0122302

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DNA methylation
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Methylation
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Metaanalysis
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Head and neck squamous cell carcinoma
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Head and neck cancers
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