Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

Hina Y Bhutta; Neetu Rajpal; Wendy White; Johannes M. Freudenberg; Yaping Liu; James Way; Deepak Rajpal; David C. Cooper; Andrew Young; Ali Tavakkoli; Lihong Chen

doi:10.1371/journal.pone.0122273

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Open Access

Peer-reviewed

Research Article

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

Hina Y Bhutta,

Affiliations Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Investigative Medicine, Imperial College, London, United Kingdom
⨯
Neetu Rajpal,

Affiliation Metabolic Drug Discovery, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Wendy White,

Affiliation Molecular Discovery Research, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Johannes M. Freudenberg,

Affiliation Quantitative Sciences Division, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Yaping Liu,

Affiliation Metabolic Drug Discovery, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
James Way,

Affiliation Metabolic Drug Discovery, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Deepak Rajpal,

Affiliation Quantitative Sciences Division, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
David C. Cooper,

Affiliation Quantitative Sciences Division, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Andrew Young,

Affiliation Metabolic Drug Discovery, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯
Ali Tavakkoli ,

* E-mail: lihong.a.chen@icloud.com (LC); atavakkoli@partners.org (AT)

Affiliations Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Lihong Chen

* E-mail: lihong.a.chen@icloud.com (LC); atavakkoli@partners.org (AT)

Affiliation Metabolic Drug Discovery, GlaxoSmithKline Inc., Research Triangle Park, North Carolina, United States of America
⨯

Effect of Roux-en-Y Gastric Bypass Surgery on Bile Acid Metabolism in Normal and Obese Diabetic Rats

Hina Y Bhutta,
Neetu Rajpal,
Wendy White,
Johannes M. Freudenberg,
Yaping Liu,
James Way,
Deepak Rajpal,
David C. Cooper,
Andrew Young,
Ali Tavakkoli

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0122273

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