AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition

Min Li; Zuolong Yang; Laura L. Vollmer; Ying Gao; Yuanyuan Fu; Cui Liu; Xiaoyun Chen; Peiqing Liu; Andreas Vogt; Xiao-Ming Yin

doi:10.1371/journal.pone.0122083

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Open Access

Peer-reviewed

Research Article

AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition

Min Li ,

* E-mail: limin65@mail.sysu.edu.cn (ML); xmyin@iupui.edu (XMY)

Affiliations School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Zuolong Yang,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Laura L. Vollmer,

Affiliation University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Ying Gao,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Yuanyuan Fu,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Cui Liu,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Xiaoyun Chen,

Affiliation Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Peiqing Liu,

Affiliation School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, Guangdong, China
⨯
Andreas Vogt,

Affiliations University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Xiao-Ming Yin

* E-mail: limin65@mail.sysu.edu.cn (ML); xmyin@iupui.edu (XMY)

Affiliation Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

AMDE-1 Is a Dual Function Chemical for Autophagy Activation and Inhibition

Min Li,
Zuolong Yang,
Laura L. Vollmer,
Ying Gao,
Yuanyuan Fu,
Cui Liu,
Xiaoyun Chen,
Peiqing Liu,
Andreas Vogt,
Xiao-Ming Yin

Published: April 20, 2015
https://doi.org/10.1371/journal.pone.0122083

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Autophagic cell death
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Cancers and neoplasms
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Proteolysis
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