Protease Activity of PprI Facilitates DNA Damage Response: Mn(2+)-Dependence and Substrate Sequence-Specificity of the Proteolytic Reaction

Yunguang Wang; Qiang Xu; Huiming Lu; Lin Lin; Liangyan Wang; Hong Xu; Xianyan Cui; Hui Zhang; Tingting Li; Yuejin Hua

doi:10.1371/journal.pone.0122071

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Open Access

Peer-reviewed

Research Article

Protease Activity of PprI Facilitates DNA Damage Response: Mn(2+)-Dependence and Substrate Sequence-Specificity of the Proteolytic Reaction

Yunguang Wang ,

Contributed equally to this work with: Yunguang Wang, Qiang Xu

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Qiang Xu ,

Contributed equally to this work with: Yunguang Wang, Qiang Xu

Affiliation Zhejiang Key Laboratory of Radiation Oncology, Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, China
⨯
Huiming Lu,

Affiliation National Institute on Aging, Biomedical Research Center, National Institutes of Health, Baltimore, United States of America
⨯
Lin Lin,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Liangyan Wang,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Hong Xu,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Xianyan Cui,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Hui Zhang,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Tingting Li,

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯
Yuejin Hua

* E-mail: yjhua@zju.edu.cn

Affiliation Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, China
⨯

Protease Activity of PprI Facilitates DNA Damage Response: Mn(2+)-Dependence and Substrate Sequence-Specificity of the Proteolytic Reaction

Yunguang Wang,
Qiang Xu,
Huiming Lu,
Lin Lin,
Liangyan Wang,
Hong Xu,
Xianyan Cui,
Hui Zhang,
Tingting Li,
Yuejin Hua

Published: March 26, 2015
https://doi.org/10.1371/journal.pone.0122071

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