Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters

Laura Staffa; Fabian Echterdiek; Nina Nelius; Axel Benner; Wiebke Werft; Bernd Lahrmann; Niels Grabe; Martin Schneider; Mirjam Tariverdian; Magnus von Knebel Doeberitz; Hendrik Bläker; Matthias Kloor

doi:10.1371/journal.pone.0121980

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Open Access

Peer-reviewed

Research Article

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters

Laura Staffa,

Affiliation Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, and Clinical Cooperation Unit Applied Tumour Biology, DKFZ (German Cancer Research Center) Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
⨯
Fabian Echterdiek,

Affiliation Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, and Clinical Cooperation Unit Applied Tumour Biology, DKFZ (German Cancer Research Center) Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
⨯
Nina Nelius,

Affiliation Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, and Clinical Cooperation Unit Applied Tumour Biology, DKFZ (German Cancer Research Center) Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
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Axel Benner,

Affiliation Department of Biostatistics, DKFZ (German Cancer Research Center), Im Neuenheimer Feld 280, Heidelberg, Germany
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Wiebke Werft,

Affiliation Department of Biostatistics, DKFZ (German Cancer Research Center), Im Neuenheimer Feld 280, Heidelberg, Germany
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Bernd Lahrmann,

Affiliation Bioquant, Hamamatsu Tissue Imaging and Analysis (TIGA) Center, Heidelberg, Germany
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Niels Grabe,

Affiliation Bioquant, Hamamatsu Tissue Imaging and Analysis (TIGA) Center, Heidelberg, Germany
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Martin Schneider,

Affiliation Department of General, Visceral and Accident Surgery, University Hospital Heidelberg, Heidelberg Germany
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Mirjam Tariverdian,

Affiliation Department of General, Visceral and Accident Surgery, University Hospital Heidelberg, Heidelberg Germany
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Magnus von Knebel Doeberitz,

Affiliation Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, and Clinical Cooperation Unit Applied Tumour Biology, DKFZ (German Cancer Research Center) Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
⨯
Hendrik Bläker ,

Contributed equally to this work with: Hendrik Bläker, Matthias Kloor

Affiliation University Hospital Charité, Department of General Pathology, Berlin, Germany
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Matthias Kloor

Contributed equally to this work with: Hendrik Bläker, Matthias Kloor

* E-mail: matthias.kloor@med.uni-heidelberg.de

Affiliation Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, and Clinical Cooperation Unit Applied Tumour Biology, DKFZ (German Cancer Research Center) Heidelberg, Im Neuenheimer Feld 280, Heidelberg, Germany
⨯

Mismatch Repair-Deficient Crypt Foci in Lynch Syndrome – Molecular Alterations and Association with Clinical Parameters

Laura Staffa,
Fabian Echterdiek,
Nina Nelius,
Axel Benner,
Wiebke Werft,
Bernd Lahrmann,
Niels Grabe,
Martin Schneider,
Mirjam Tariverdian,
Magnus von Knebel Doeberitz

Published: March 27, 2015
https://doi.org/10.1371/journal.pone.0121980

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