Repositioning of Memantine as a Potential Novel Therapeutic Agent against Meningitic E. coli–Induced Pathogenicities through Disease-Associated Alpha7 Cholinergic Pathway and RNA Sequencing-Based Transcriptome Analysis of Host Inflammatory Responses

• Jing-Yi Yu ,

  Contributed equally to this work with: Jing-Yi Yu, Bao Zhang

  Affiliations Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China, Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America

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• Bao Zhang ,

  Contributed equally to this work with: Jing-Yi Yu, Bao Zhang

  Affiliations Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China, Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America

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• Liang Peng,

  Affiliations Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America, Department of Clinic Laboratory, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, China

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• Chun-Hua Wu,

  Affiliation Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America

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• Hong Cao,

  Affiliation Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China

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• John F. Zhong,

  Affiliations Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, United States of America, Department of Perio, Diagnostic Sciences & Biomedical Sciences, School of Dentistry, University of Southern California, Los Angeles, CA, 93003, United States of America, Department of Pediatrics, School of Medicine, University of Southern California, Los Angeles, CA, 93003, United States of America

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• Jill Hoffman,

  Affiliation Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America

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• Sheng-He Huang

  * E-mail: shhuang@hsc.usc.edu

  Affiliations Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China, Saban Research Institute of Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90027, United States of America

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