Appropriateness of Using Patient-Derived Xenograft Models for Pharmacologic Evaluation of Novel Therapies for Esophageal/Gastro-Esophageal Junction Cancers

• Lorin Dodbiba,

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Wayne State University, School of Medicine, Detroit, Michigan, United States of America

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• Jennifer Teichman,

  Affiliation Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

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• Andrew Fleet,

  Affiliation Ontario Cancer Institute, Toronto, ON, Canada

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• Henry Thai,

  Affiliation University Health Network, Princess Margaret Hospital, Toronto, ON, Canada

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• Maud H. W. Starmans,

  Affiliations Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada, Department of Radiation Oncology (Maastro), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands

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• Roya Navab,

  Affiliation Ontario Cancer Institute, Toronto, ON, Canada

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• Zhuo Chen,

  Affiliation Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

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• Hala Girgis,

  Affiliation Department of Anatomical Pathology, Toronto General Hospital, Toronto, ON, Canada

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• Lawson Eng,

  Affiliation Ontario Cancer Institute, Toronto, ON, Canada

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• Osvaldo Espin-Garcia,

  Affiliation Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada

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• Xiaowei Shen,

  Affiliation Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada

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• Bizhan Bandarchi,

  Affiliation Ontario Cancer Institute, Toronto, ON, Canada

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• Joerg Schwock,

  Affiliation Department of Anatomical Pathology, Toronto General Hospital, Toronto, ON, Canada

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• Ming-Sound Tsao,

  Affiliations Ontario Cancer Institute, Toronto, ON, Canada, University Health Network, Princess Margaret Hospital, Toronto, ON, Canada, Department of Anatomical Pathology, Toronto General Hospital, Toronto, ON, Canada

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• Hala El-Zimaity,

  Affiliations University Health Network, Princess Margaret Hospital, Toronto, ON, Canada, Department of Anatomical Pathology, Toronto General Hospital, Toronto, ON, Canada

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• Sandy D. Der,

  Affiliation Ontario Cancer Institute, Toronto, ON, Canada

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• Wei Xu,

  Affiliations Department of Biostatistics, Princess Margaret Hospital, Toronto, Canada, Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada

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• Robert G. Bristow,

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Ontario Cancer Institute, Toronto, ON, Canada

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• Gail E. Darling,

  Affiliation Division of Thoracic Surgery, Toronto General Hospital, Toronto, ON, Canada

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• Paul C. Boutros,

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Informatics and Biocomputing Program, Ontario Institute for Cancer Research, Toronto, Canada, Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada

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• Laurie E. Ailles ,

  Contributed equally to this work with: Laurie E. Ailles, Geoffrey Liu

  ¶‡ GL and LEA are joint senior authors on this work.

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Ontario Cancer Institute, Toronto, ON, Canada

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•  [ ... ],
• Geoffrey Liu

  Contributed equally to this work with: Laurie E. Ailles, Geoffrey Liu

  * E-mail: geoffrey.liu@uhn.ca

  ¶‡ GL and LEA are joint senior authors on this work.

  Affiliations Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, Ontario Cancer Institute, Toronto, ON, Canada, Division of Epidemiology, Dalla Lana School of Public Health, Toronto, Canada

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