Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism

Open Access

Peer-reviewed

Research Article

Xiuwei Wang,

Affiliation Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China
⨯
Zhen Guan,

Affiliation Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China
⨯
Yan Chen,

Affiliation Department of Respiratory, the Second Hospital of Shanxi Medical University, Taiyuan, China
⨯
Yanting Dong,

Affiliation Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China
⨯
Yuhu Niu,

Affiliation Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China
⨯
Jianhua Wang,

Affiliation Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China
⨯
Ting Zhang ,

* E-mail: niub2004@126.com (BN); zhangtingcv@yahoo.com (TZ)

Affiliation Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China
⨯
Bo Niu

* E-mail: niub2004@126.com (BN); zhangtingcv@yahoo.com (TZ)

Affiliations Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China, Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, China
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DNA methylation
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Neural tube defects
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Mammalian genomics
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Polymerase chain reaction
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Microarrays
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Gene expression
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Folic acid
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Wnt signaling cascade
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