Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner; Darlene Romashko; Douglas S. Werner; Earl W. May; Yue Peng; Ryan Schulz; Kenneth W. Foreman; Suzanne Russo; Lee D. Arnold; Maneesh Pingle; Donald E. Bergstrom; Francis Barany; Stuart Thomson

doi:10.1371/journal.pone.0121793

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Open Access

Peer-reviewed

Research Article

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Darlene Romashko,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Douglas S. Werner,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Earl W. May,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Yue Peng,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Ryan Schulz,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Kenneth W. Foreman,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Suzanne Russo,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Lee D. Arnold,

Current address: Assembly Biosciences Inc., New York, New York, United States of America

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Maneesh Pingle,

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯
Donald E. Bergstrom,

Affiliation Purdue University, West Lafayette, Indiana, United States of America
⨯
Francis Barany,

Affiliation Department of Microbiology, Weill Cornell Medical College, New York, New York, United States of America
⨯
Stuart Thomson

* E-mail: sthomson@coferon.com

Affiliation Coferon Inc, 25 Health Sciences Drive, Stony Brook, New York, United States of America
⨯

Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner,
Darlene Romashko,
Douglas S. Werner,
Earl W. May,
Yue Peng,
Ryan Schulz,
Kenneth W. Foreman,
Suzanne Russo,
Lee D. Arnold,
Maneesh Pingle

Published: April 15, 2015
https://doi.org/10.1371/journal.pone.0121793

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Monomers
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Small molecules
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