A Mouse Model of Human Primitive Neuroectodermal Tumors Resulting from Microenvironmentally-Driven Malignant Transformation of Orthotopically Transplanted Radial Glial Cells

• Sergey Malchenko,

  Affiliations Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Simone Treiger Sredni,

  Affiliations Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Division of Pediatric Neurosurgery, Department of Surgery, Ann & Robert H. Lurie Children’s Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Hitoshi Hashimoto,

  Affiliations Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan, iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan, Molecular Research Center for Children’s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan

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• Atsushi Kasai,

  Affiliations Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan, Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, 1–1 Yamadaoka, Suita, Osaka, Japan

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• Kazuki Nagayasu,

  Affiliations Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan, iPS Cell-based Research Project on Brain Neuropharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan

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• Jianping Xie,

  Affiliation Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America

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• Naira V. Margaryan,

  Affiliation Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America

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• Kaoru Seiriki,

  Affiliations Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1–6 Yamadaoka, Suita, Osaka, Japan, Interdisciplinary Program for Biomedical Sciences, Institute for Academic Initiatives, Osaka University, 1–1 Yamadaoka, Suita, Osaka, Japan

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• Rishi R. Lulla,

  Affiliations Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Division of Hematology/Oncology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Richard E. B. Seftor,

  Affiliations Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Lauren M. Pachman,

  Affiliation Cure-Juvenile Myositis Program of Excellence, Division of Pediatric Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Herbert Y. Meltzer,

  Affiliation Psychiatry & Behavioral Sciences at the Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Mary J. C. Hendrix,

  Affiliations Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Marcelo B. Soares

  * E-mail: m-soares@northwestern.edu

  Affiliations Cancer Biology and Epigenomics Program, Stanley Manne Children’s Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Division of Hematology/Oncology, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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