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Open Access
Peer-reviewed
Research Article
Population Genomic Analysis of 962 Whole Genome Sequences of Humans Reveals Natural Selection in Non-Coding Regions
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Fuli Yu ,
Contributed equally to this work with: Fuli Yu, Jian Lu, Xiaoming Liu
* E-mail: fyu@bcm.edu (FY); Eric.Boerwinkle@uth.tmc.edu (EB)
Affiliations Human Genome Sequencing Center, Molecular and Human Genetics Department, Baylor College of Medicine, Houston, Texas, United States of America, Institute of Neurology, Tianjin Medical University General Hospital, Tianjin, China
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Jian Lu ,
Contributed equally to this work with: Fuli Yu, Jian Lu, Xiaoming Liu
Affiliations Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America, College of Life Sciences, State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
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Xiaoming Liu ,
Contributed equally to this work with: Fuli Yu, Jian Lu, Xiaoming Liu
Affiliation Human Genetic Center, University of Texas Health Science Center, Houston, Texas, United States of America
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Elodie Gazave,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Diana Chang,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Srilakshmi Raj,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Haley Hunter-Zinck,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Ran Blekhman,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Leonardo Arbiza,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Cris Van Hout,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Alanna Morrison,
Affiliation Human Genetic Center, University of Texas Health Science Center, Houston, Texas, United States of America
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Andrew D. Johnson,
Affiliation National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America
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Joshua Bis,
Affiliation Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, United States of America
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L. Adrienne Cupples,
Affiliation National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, United States of America
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Bruce M. Psaty,
Affiliation Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, United States of America
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Donna Muzny,
Affiliation Human Genome Sequencing Center, Molecular and Human Genetics Department, Baylor College of Medicine, Houston, Texas, United States of America
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Jin Yu,
Affiliation Human Genome Sequencing Center, Molecular and Human Genetics Department, Baylor College of Medicine, Houston, Texas, United States of America
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Richard A. Gibbs,
Affiliation Human Genome Sequencing Center, Molecular and Human Genetics Department, Baylor College of Medicine, Houston, Texas, United States of America
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Alon Keinan,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Andrew G. Clark,
Affiliation Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, New York, United States of America
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Eric Boerwinkle
* E-mail: fyu@bcm.edu (FY); Eric.Boerwinkle@uth.tmc.edu (EB)
Affiliations Human Genome Sequencing Center, Molecular and Human Genetics Department, Baylor College of Medicine, Houston, Texas, United States of America, Human Genetic Center, University of Texas Health Science Center, Houston, Texas, United States of America
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Population Genomic Analysis of 962 Whole Genome Sequences of Humans Reveals Natural Selection in Non-Coding Regions
- Fuli Yu,
- Jian Lu,
- Xiaoming Liu,
- Elodie Gazave,
- Diana Chang,
- Srilakshmi Raj,
- Haley Hunter-Zinck,
- Ran Blekhman,
- Leonardo Arbiza,
- Cris Van Hout
- Published: March 25, 2015
- https://doi.org/10.1371/journal.pone.0121644