Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8+ T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7

Open Access

Peer-reviewed

Research Article

Codon Optimization of the Human Papillomavirus E7 Oncogene Induces a CD8⁺ T Cell Response to a Cryptic Epitope Not Harbored by Wild-Type E7

Felix K. M. Lorenz,

Affiliation Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Susanne Wilde,

Affiliation Institute for Molecular Immunology, Helmholtz-Zentrum München, Munich, Germany
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Katrin Voigt,

Affiliation Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
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Elisa Kieback,

Affiliation Institute of Biology, Humboldt University, Berlin, Germany
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Barbara Mosetter,

Affiliation Institute for Molecular Immunology, Helmholtz-Zentrum München, Munich, Germany
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Dolores J. Schendel,

Affiliation Institute for Molecular Immunology, Helmholtz-Zentrum München, Munich, Germany
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Wolfgang Uckert

* E-mail: wuckert@mdc-berlin.de

Affiliations Max-Delbrück-Center for Molecular Medicine, Berlin, Germany, Institute of Biology, Humboldt University, Berlin, Germany
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T cells
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T cell receptors
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Gene prediction
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Major histocompatibility complex
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Antigens
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HPV-16
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Cytotoxic T cells
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Epitope mapping
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