IMD-4690, a Novel Specific Inhibitor for Plasminogen Activator Inhibitor-1, Reduces Allergic Airway Remodeling in a Mouse Model of Chronic Asthma via Regulating Angiogenesis and Remodeling-Related Mediators

• Toshifumi Tezuka,

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Hirohisa Ogawa,

  Affiliation Department of Molecular and Environmental Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Masahiko Azuma,

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Hisatsugu Goto,

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Hisanori Uehara,

  Affiliation Department of Molecular and Environmental Pathology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Yoshinori Aono,

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Masaki Hanibuchi,

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯
• Yoichi Yamaguchi,

  Affiliation Institute of Medicinal Molecular Design Inc., Tokyo, Japan

  ⨯
• Tomoyuki Fujikawa,

  Affiliation Institute of Medicinal Molecular Design Inc., Tokyo, Japan

  ⨯
• Akiko Itai,

  Affiliation Institute of Medicinal Molecular Design Inc., Tokyo, Japan

  ⨯
• Yasuhiko Nishioka

  * E-mail: yasuhiko@tokushima-u.ac.jp

  Affiliation Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan

  ⨯