Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells

Nicoletta Bianchi; Alessia Finotti; Manuela Ferracin; Ilaria Lampronti; Cristina Zuccato; Giulia Breveglieri; Eleonora Brognara; Enrica Fabbri; Monica Borgatti; Massimo Negrini; Roberto Gambari

doi:10.1371/journal.pone.0121567

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Peer-reviewed

Research Article

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells

Nicoletta Bianchi,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Alessia Finotti,

Affiliations Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy, Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassaemia, Biotechnology Center, Ferrara University, Ferrara, Italy
⨯
Manuela Ferracin,

Affiliations Department of Morphology, Surgery and Experimental Medicine, Ferrara University, Ferrara, Italy, Laboratory for Technologies of Advanced Therapies (LTTA), Ferrara University, Ferrara, Italy
⨯
Ilaria Lampronti,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Cristina Zuccato,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Giulia Breveglieri,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Eleonora Brognara,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Enrica Fabbri,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Monica Borgatti,

Affiliation Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy
⨯
Massimo Negrini,

Affiliations Department of Morphology, Surgery and Experimental Medicine, Ferrara University, Ferrara, Italy, Laboratory for Technologies of Advanced Therapies (LTTA), Ferrara University, Ferrara, Italy
⨯
Roberto Gambari

* E-mail: gam@unife.it

Affiliations Department of Life Sciences and Biotechnology, Ferrara University, Ferrara, Italy, Laboratory for the Development of Pharmacological and Pharmacogenomic Therapy of Thalassaemia, Biotechnology Center, Ferrara University, Ferrara, Italy
⨯

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells

Nicoletta Bianchi,
Alessia Finotti,
Manuela Ferracin,
Ilaria Lampronti,
Cristina Zuccato,
Giulia Breveglieri,
Eleonora Brognara,
Enrica Fabbri,
Monica Borgatti,
Massimo Negrini

Published: April 7, 2015
https://doi.org/10.1371/journal.pone.0121567

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Raptors
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MicroRNAs
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Gene expression
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Cell differentiation
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Messenger RNA
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Hemoglobin
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Small interfering RNA
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