Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

Anchel González-Barriga; Julia Kranzen; Huib J. E. Croes; Suzanne Bijl; Walther J. A. A. van den Broek; Ingeborg D. G. van Kessel; Baziel G. M. van Engelen; Judith C. T. van Deutekom; Bé Wieringa; Susan A. M. Mulders; Derick G. Wansink

doi:10.1371/journal.pone.0121556

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Open Access

Peer-reviewed

Research Article

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

Anchel González-Barriga,

Affiliations Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands, Prosensa Therapeutics B.V., Leiden, The Netherlands
⨯
Julia Kranzen,

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯
Huib J. E. Croes,

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯
Suzanne Bijl,

Affiliation Prosensa Therapeutics B.V., Leiden, The Netherlands
⨯
Walther J. A. A. van den Broek,

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯
Ingeborg D. G. van Kessel,

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯
Baziel G. M. van Engelen,

Affiliation Department of Neurology, Donders Centre for Neuroscience, Radboud university medical center, Nijmegen, The Netherlands
⨯
Judith C. T. van Deutekom,

Affiliation Prosensa Therapeutics B.V., Leiden, The Netherlands
⨯
Bé Wieringa,

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯
Susan A. M. Mulders,

Affiliations Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands, Prosensa Therapeutics B.V., Leiden, The Netherlands
⨯
Derick G. Wansink

* E-mail: rick.wansink@radboudumc.nl

Affiliation Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud university medical center, Nijmegen, The Netherlands
⨯

Cell Membrane Integrity in Myotonic Dystrophy Type 1: Implications for Therapy

Anchel González-Barriga,
Julia Kranzen,
Huib J. E. Croes,
Suzanne Bijl,
Walther J. A. A. van den Broek,
Ingeborg D. G. van Kessel,
Baziel G. M. van Engelen,
Judith C. T. van Deutekom,
Bé Wieringa,
Susan A. M. Mulders

Published: March 23, 2015
https://doi.org/10.1371/journal.pone.0121556

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Cell membranes
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Mouse models
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Dystrophin
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Skeletal muscles
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Biopsy
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Cardiac muscles
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Muscle proteins
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Myotonic dystrophy
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