Pre-Analytical Sample Quality: Metabolite Ratios as an Intrinsic Marker for Prolonged Room Temperature Exposure of Serum Samples

Gabriele Anton; Rory Wilson; Zhong-hao Yu; Cornelia Prehn; Sven Zukunft; Jerzy Adamski; Margit Heier; Christa Meisinger; Werner Römisch-Margl; Rui Wang-Sattler; Kristian Hveem; Bruce Wolfenbuttel; Annette Peters; Gabi Kastenmüller; Melanie Waldenberger

doi:10.1371/journal.pone.0121495

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Open Access

Peer-reviewed

Research Article

Pre-Analytical Sample Quality: Metabolite Ratios as an Intrinsic Marker for Prolonged Room Temperature Exposure of Serum Samples

Gabriele Anton ,

* E-mail: gabriele.anton@helmholtz-muenchen.de

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯
Rory Wilson,

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯
Zhong-hao Yu,

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯
Cornelia Prehn,

Affiliation Institute of Experimental Genetics, Helmholtz Center Munich, Munich, Germany
⨯
Sven Zukunft,

Affiliation Institute of Experimental Genetics, Helmholtz Center Munich, Munich, Germany
⨯
Jerzy Adamski,

Affiliation Institute of Experimental Genetics, Helmholtz Center Munich, Munich, Germany
⨯
Margit Heier,

Affiliations Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany, Central Hospital of Augsburg, KORA Myocardial Infarction Registry, Augsburg, Germany
⨯
Christa Meisinger,

Affiliations Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany, Central Hospital of Augsburg, KORA Myocardial Infarction Registry, Augsburg, Germany
⨯
Werner Römisch-Margl,

Affiliation Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich, Munich, Germany
⨯
Rui Wang-Sattler,

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯
Kristian Hveem,

Affiliation Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway
⨯
Bruce Wolfenbuttel,

Affiliation Department of Endocrinology, University Medical Center Groningen, Groningen, The Netherlands
⨯
Annette Peters,

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯
Gabi Kastenmüller,

Affiliation Institute for Bioinformatics and Systems Biology, Helmholtz Center Munich, Munich, Germany
⨯
Melanie Waldenberger

Affiliation Institute of Epidemiology II, Helmholtz Center Munich, Munich, Germany
⨯

Pre-Analytical Sample Quality: Metabolite Ratios as an Intrinsic Marker for Prolonged Room Temperature Exposure of Serum Samples

Gabriele Anton,
Rory Wilson,
Zhong-hao Yu,
Cornelia Prehn,
Sven Zukunft,
Jerzy Adamski,
Margit Heier,
Christa Meisinger,
Werner Römisch-Margl,
Rui Wang-Sattler

Published: March 30, 2015
https://doi.org/10.1371/journal.pone.0121495

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Metabolites
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Amino acid metabolism
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Phenylalanine
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Specimen storage
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Glycine
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