IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment

Subhash Gaddipati; Qingxian Lu; Ramesh Babu Kasetti; M. Clarke Miller; Qingjun Lu; John O. Trent; Henry J. Kaplan; Qiutang Li

doi:10.1371/journal.pone.0121185

Loading metrics

Open Access

Peer-reviewed

Research Article

IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment

Subhash Gaddipati,

Affiliations Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Qingxian Lu,

Affiliations Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Ramesh Babu Kasetti,

Affiliation Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
M. Clarke Miller,

Affiliations James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Chemistry and Biochemistry, University of North Georgia, Oakwood, Georgia, United States of America
⨯
Qingjun Lu,

Affiliation Beijing Institute of Ophthalmology, Beijing Tong-Ren Eye Center, Capital Medical University, Beijing, China
⨯
John O. Trent,

Affiliations James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Henry J. Kaplan,

Affiliation Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯
Qiutang Li

* E-mail: q.li@louisville.edu

Affiliations Departments of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, Kentucky, United States of America, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
⨯

IKK2 Inhibition Using TPCA-1-Loaded PLGA Microparticles Attenuates Laser-Induced Choroidal Neovascularization and Macrophage Recruitment

Subhash Gaddipati,
Qingxian Lu,
Ramesh Babu Kasetti,
M. Clarke Miller,
Qingjun Lu,
John O. Trent,
Henry J. Kaplan,
Qiutang Li

Published: March 24, 2015
https://doi.org/10.1371/journal.pone.0121185

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Eyes
Is the Subject Area "Eyes" applicable to this article?

Thanks for your feedback.
Lasers
Is the Subject Area "Lasers" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Microspheres
Is the Subject Area "Microspheres" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Retina
Is the Subject Area "Retina" applicable to this article?

Thanks for your feedback.
Drug administration
Is the Subject Area "Drug administration" applicable to this article?

Thanks for your feedback.