A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

Gaynor A. Smith; Emily M. Rocha; Thomas Rooney; Pascal Barneoud; Jesse R. McLean; Jonathan Beagan; Teresia Osborn; Madeleine Coimbra; Yongyi Luo; Penelope J. Hallett; Ole Isacson

doi:10.1371/journal.pone.0121072

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Peer-reviewed

Research Article

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

Gaynor A. Smith ,

Contributed equally to this work with: Gaynor A. Smith, Emily M. Rocha

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Emily M. Rocha ,

Contributed equally to this work with: Gaynor A. Smith, Emily M. Rocha

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Thomas Rooney,

Affiliation Sanofi, Neurodegeneration and Pain Unit, Chilly-Mazarin, France
⨯
Pascal Barneoud,

Affiliation Sanofi, Neurodegeneration and Pain Unit, Chilly-Mazarin, France
⨯
Jesse R. McLean,

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Jonathan Beagan,

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Teresia Osborn,

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Madeleine Coimbra,

Affiliation Sanofi, Disposition, Safety & Animal Research, Department 1, Chilly-Mazarin, France
⨯
Yongyi Luo,

Affiliation Sanofi-Genzyme, Drug Metabolism and Pharmacokinetics Department, Waltham, Massachusetts, United States of America
⨯
Penelope J. Hallett ,

* E-mail: Isacson@hms.harvard.edu (OI); PHallett@mclean.harvard.edu (PJH)

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯
Ole Isacson

* E-mail: Isacson@hms.harvard.edu (OI); PHallett@mclean.harvard.edu (PJH)

Affiliation Neuroregeneration Research Institute, Harvard Medical School/McLean Hospital, Belmont, Massachusetts, United States of America
⨯

A Nurr1 Agonist Causes Neuroprotection in a Parkinson’s Disease Lesion Model Primed with the Toll-Like Receptor 3 dsRNA Inflammatory Stimulant Poly(I:C)

Gaynor A. Smith,
Emily M. Rocha,
Thomas Rooney,
Pascal Barneoud,
Jesse R. McLean,
Jonathan Beagan,
Teresia Osborn,
Madeleine Coimbra,
Yongyi Luo,
Penelope J. Hallett

Published: March 27, 2015
https://doi.org/10.1371/journal.pone.0121072

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