IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Reto Guler; Suraj P. Parihar; Suzana Savvi; Erin Logan; Anita Schwegmann; Sugata Roy; Natalie E. Nieuwenhuizen; Mumin Ozturk; Sebastian Schmeier; Harukazu Suzuki; Frank Brombacher

doi:10.1371/journal.pone.0121070

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Open Access

Peer-reviewed

Research Article

IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Reto Guler ,

Contributed equally to this work with: Reto Guler, Suraj P. Parihar

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Suraj P. Parihar ,

Contributed equally to this work with: Reto Guler, Suraj P. Parihar

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Suzana Savvi,

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Erin Logan,

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Anita Schwegmann,

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Sugata Roy,

Affiliation RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan
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Natalie E. Nieuwenhuizen,

Current address: Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Mumin Ozturk,

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯
Sebastian Schmeier,

Affiliation Massey University, Institute of Natural and Mathematical Sciences, Auckland, New Zealand
⨯
Harukazu Suzuki,

Affiliation RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan
⨯
Frank Brombacher

* E-mail: frank.brombacher@icgeb.org

Affiliation International Centre for Genetic Engineering & Biotechnology (ICGEB), Cape Town component and Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology, University of Cape Town, Cape Town, South Africa
⨯

IL-4Rα-Dependent Alternative Activation of Macrophages Is Not Decisive for Mycobacterium tuberculosis Pathology and Bacterial Burden in Mice

Reto Guler,
Suraj P. Parihar,
Suzana Savvi,
Erin Logan,
Anita Schwegmann,
Sugata Roy,
Natalie E. Nieuwenhuizen,
Mumin Ozturk,
Sebastian Schmeier,
Harukazu Suzuki

Published: March 19, 2015
https://doi.org/10.1371/journal.pone.0121070

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Mycobacterium tuberculosis
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T cells
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