The Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo

Barbara Blouw; Manishha Patel; Shinji Iizuka; Christopher Abdullah; Weon Kyoo You; Xiayu Huang; Jian-Liang Li; Begoña Diaz; William B. Stallcup; Sara A. Courtneidge

doi:10.1371/journal.pone.0121003

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Open Access

Peer-reviewed

Research Article

The Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo

Barbara Blouw,

Current address: Genoptix Medical Laboratory, Carlsbad, CA, United States of America

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Manishha Patel,

Current address: Genomics Institute of the Novartis Research Foundation, San Diego, CA, United States of America

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Shinji Iizuka,

Current address: Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, United States of America

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Christopher Abdullah,

Current address: Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, United States of America

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Weon Kyoo You,

Current address: Biologics Business, Research and Development Center, Hanwha Chemical, Daejeon, South Korea

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Xiayu Huang,

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Jian-Liang Li,

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Begoña Diaz,

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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William B. Stallcup,

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
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Sara A. Courtneidge

* E-mail: courtneidge@ohsu.edu

Current address: Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR, United States of America

Affiliation Tumor Microenvironment and Metastasis Program, NCI Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
⨯

The Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo

Barbara Blouw,
Manishha Patel,
Shinji Iizuka,
Christopher Abdullah,
Weon Kyoo You,
Xiayu Huang,
Jian-Liang Li,
Begoña Diaz,
William B. Stallcup,
Sara A. Courtneidge

Published: March 31, 2015
https://doi.org/10.1371/journal.pone.0121003

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