Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study

Wolfgang Klein; Carolin Westendorf; Antje Schmidt; Mercè Conill-Cortés; Claudia Rutz; Marcus Blohs; Michael Beyermann; Jonas Protze; Gerd Krause; Eberhard Krause; Ralf Schülein

doi:10.1371/journal.pone.0120886

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Peer-reviewed

Research Article

Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study

Wolfgang Klein,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Carolin Westendorf,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Antje Schmidt,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Mercè Conill-Cortés,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Claudia Rutz,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Marcus Blohs,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Michael Beyermann,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Jonas Protze,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Gerd Krause,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Eberhard Krause,

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯
Ralf Schülein

* E-mail: schuelein@fmp-berlin.de

Affiliation Leibniz-Institut für Molekulare Pharmakologie (FMP), Robert-Rössle-Str. 10, 13125, Berlin, Germany
⨯

Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study

Wolfgang Klein,
Carolin Westendorf,
Antje Schmidt,
Mercè Conill-Cortés,
Claudia Rutz,
Marcus Blohs,
Michael Beyermann,
Jonas Protze,
Gerd Krause,
Eberhard Krause

Published: March 25, 2015
https://doi.org/10.1371/journal.pone.0120886

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Integral membrane proteins
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Membrane proteins
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Sequence motif analysis
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Protein secretion
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HEK 293 cells
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