Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1

Shohei Yamamoto; Makoto Otsu; Emiko Matsuzaka; Chieko Konishi; Haruna Takagi; Sachiyo Hanada; Shinji Mochizuki; Hiromitsu Nakauchi; Kohzoh Imai; Kohichiro Tsuji; Yasuhiro Ebihara

doi:10.1371/journal.pone.0120841

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Open Access

Peer-reviewed

Research Article

Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1

Shohei Yamamoto,

Affiliations Department of Pediatric Hematology/Oncology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Makoto Otsu,

Affiliations Department of Pediatric Hematology/Oncology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯
Emiko Matsuzaka,

Affiliation Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Chieko Konishi,

Affiliation Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Haruna Takagi,

Affiliation Stem Cell Bank, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Sachiyo Hanada,

Affiliation Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Shinji Mochizuki,

Affiliations Department of Pediatric Hematology/Oncology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Hiromitsu Nakauchi,

Affiliation Division of Stem Cell Therapy, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Kohzoh Imai,

Affiliation Center for Antibody and Vaccine, IMSUT Hospital, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
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Kohichiro Tsuji,

Affiliations Department of Pediatric Hematology/Oncology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, National Hospital Organization Shinshu Ueda Medical Center, Ueda, Japan
⨯
Yasuhiro Ebihara

* E-mail: ebihara@ims.u-tokyo.ac.jp

Affiliations Department of Pediatric Hematology/Oncology, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Stem Cell Processing, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Division of Advanced Regenerative Medicine, Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
⨯

Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1

Shohei Yamamoto,
Makoto Otsu,
Emiko Matsuzaka,
Chieko Konishi,
Haruna Takagi,
Sachiyo Hanada,
Shinji Mochizuki,
Hiromitsu Nakauchi,
Kohzoh Imai,
Kohichiro Tsuji

Published: March 24, 2015
https://doi.org/10.1371/journal.pone.0120841

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